Introduction

Living organisms are organized in multiple scales. A myriad of small molecules such as proteins form a complex and dynamic network of chemical reactions. Their spatiotemporal interactions regulate cell physiology (i.e. dynamics of the cell). Cells also communicate with each other to integrate themselves into tissues. Finally, various tissues arrange themselves into organs, and many organs compose an organism. We aim to develop mathematical toolboxes for investigating such multiscale systems of living organisms and apply them to improve our understanding for living systems.

• - Development of reduction methods for multi-scale systems and its application to identify molecular mechanisms underlying enzyme kinetics, cancer immunotherapy and biological oscillators.
• - Development of inference methods for dynamic cellular networks and its application to biological oscillatory networks.
• - Development of digital medicine for sleep disorders and cancer based on health wearable devices.